Bruce R. Donald
CS Department Image
James B. Duke Distinguished Professor of Computer Science, Professor of Chemistry, Professor of Biochemistry, Professor of Mathematics, Professor of Electrical and Computer Engineering, Faculty Network Member of the Duke Institute for Brain Sciences, Bass Fellow
Faculty Group: Artificial Intelligence
Email brd at
Office D212 LSRC
Phone (919) 660-6583
Web page


Ph.D., Computer Science, MIT 1987
S.M., Electrical Engineering & Computer Science, MIT 1984
B.A., summa cum laude , Yale 1980

Honors & Awards

NSF Presidential Young Investigator (1989)
John Simon Guggenheim Memorial Fellow (2001)
Fellow of the ACM (2009)
Fellow of the IEEE (2011)
Advisory Committee for Cyberinfrastructure, NSF (2012-2014)
Fellow of the AAAS (2015)


Computational Biology, Computational Chemistry, Structural Biology, Biochemistry, Protein Design, Drug Design, NMR of Biological Macromolecules, Microelectromechanical Systems (MEMS), Micro-robotics, Geometric Algorithms

Selected Publications

  • "Computational structure-based redesign of enzyme activity." Proceedings of the National Academy of Sciences (PNAS) U.S.A. 2009;106(10):3764-3769. (abstract)
  • "Protein Design Algorithms Predict Viable Resistance to an Experimental Antifolate." Proceedings of the National Academy of Sciences (PNAS) U.S.A. 2015;112(3):749-745. (abstract)
  • "Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env." Nature Structural & Molecular Biology 2015; (22) pp. 522-531. (abstract)
  • "Planar Microassembly by Parallel Actuation of MEMS Microrobots." Journal of Microelectromechanical Systems 2008; 17(4): 789-808. (pdf, videos)
  • "Kinodynamic Motion Planning." Journal of the ACM Vol. 40, No. 5, 1993. pp. 1048-1066. (pdf)

Extended List of Publications

Publications by Bruce R. Donald